MOTS-C Overview

MOTS-C is a mitochondrial-derived peptide encoded by the mitochondrial 12S rRNA gene, crucial in metabolic regulation, stress response, and aging. Discovered in 2015, it’s known to regulate glucose uptake, lipid metabolism, and insulin sensitivity. Its expression is induced by stress and exercise, and it operates mainly via the Folate-AICAR-AMPK pathway, impacting energy metabolism and insulin resistance. MOTS-c’s levels decrease with age, and studies have shown potential therapeutic applications for metabolic disorders.

Product Details

• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
• Molecular Formula: C101H152N28O22S2
• Molecular Weight: 2174.64 g/mol
• PubChem SID: 255386757
• CAS Number: 1627580-64-6

Research Highlights

1. MOTS-C & Heart Health: Shows potential in reducing heart dysfunction and counteracting heart failure progression by managing oxidative stress and inflammation. The activation of the AMPK pathway suggests benefits for cardiac health and function under stress.
2. MOTS-C & Muscle and Fat Metabolism: Influences muscle and fat metabolism, playing a role in weight management and overall metabolic health. Its regulation of energy use and insulin sensitivity is vital for metabolic balance, with implications for conditions like diabetes and metabolic syndrome.