MOTS-C Overview

MOTS-C is a mitochondrial-derived peptide encoded by the 12S rRNA gene, extensively studied in laboratory settings for its role in cellular energy regulation and stress adaptation pathways. Discovered in 2015, it has become a focus in experimental research related to mitochondrial signaling, energy homeostasis, and peptide-mediated metabolic modulation. Its function is largely associated with the Folate-AICAR-AMPK axis, making it a valuable candidate for metabolic pathway modeling in research environments.

Product Details

• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
• Molecular Formula: C101H152N28O22S2
• Molecular Weight: 2174.64 g/mol
• PubChem SID: 255386757
• CAS Number: 1627580-64-6

Research Highlights

1. AMPK Pathway Activation: MOTS-C has been studied for its ability to influence the AMPK signaling cascade, a key regulator in cellular energy homeostasis and stress response under laboratory conditions.
2. Mitochondrial Signaling Studies: Research indicates that MOTS-C expression responds to cellular stress stimuli and nutrient availability, contributing to its use in studies involving mitochondrial dynamics and metabolic modeling.
3. Experimental Observations in Energy Regulation: In preclinical models, MOTS-C has been linked to modulation of substrate utilization and regulatory peptide responses, offering insights into adaptive energy mechanisms.

Usage and Safety Information

This product is intended for laboratory research use only. It is not approved for human or veterinary applications. All experiments should be conducted in accordance with applicable research safety protocols and legal regulations.