Kisspeptin-10 Overview

Kisspeptin-10 is a synthetic decapeptide derived from the endogenous KISS1 protein, known for its role as a ligand for the GPR54 (KISS1R) receptor. It is widely utilized in laboratory environments to study reproductive signaling pathways, hypothalamic–pituitary interactions, peptide–receptor binding, and the regulation of neuroendocrine axes. Kisspeptin-10’s short, active fragment enables precise in vitro modeling of upstream signaling in GnRH-associated pathways.

Product Details

• Product Name: Kisspeptin-10
• Chemical Name: Metastin (45–54) amide
• Molecular Formula: C59H75N17O14
• Molecular Weight: 1302.33 g/mol
• CAS Number: 191825-97-5
• Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
• Appearance: White to off-white lyophilized powder
• Purity: ≥ 98%
• Storage Conditions: Store in a cool, dry environment. Refrigeration recommended for extended stability.

Laboratory Notes

Kisspeptin-10 is commonly employed in research exploring GPR54 receptor activation, GnRH neuron signaling, reproductive axis modulation, and intracellular pathways such as ERK1/2 and PLC activation. Due to its high receptor affinity and structural simplicity, it serves as a valuable tool for studying upstream control of hypothalamic signaling and neuropeptide interactions in vitro.

Usage & Handling

For laboratory research use only. Not intended for human or animal consumption. All handling should comply with appropriate laboratory safety procedures and institutional guidelines.

Storage Guidelines

Store the lyophilized peptide in a tightly sealed container, protected from moisture and light. Refrigeration at 2–8°C is recommended for long-term stability. Avoid repeated freeze–thaw cycles.

Disclaimer

This compound is provided exclusively for scientific research purposes. Sigma Peptides does not make or imply any claims relating to human or animal health. Not for diagnostic, therapeutic, or clinical use.